![]() However, notall of theseeffects have been clearlyconfirmed. It also exerts an impact on L‐arginine in the nitric oxide (NO) synthesis pathway. Additionally, paracetamol influences transient receptor potential (TRP) channels and voltage‐gated Kv7 potassium channels and inhibits T‐type Cav3.2 calcium channels. ![]() The mechanism of paracetamol action consists in inhibition of cyclooxygenases (COX‐1, COX‐2, and COX‐3) and involvement in the endocannabinoid system and serotonergic pathways. Despite its popularity and use for many years, the safety of its application and its mechanism of action are still unclear.Currently, it is believed that paracetamol is a multidirectional drug and at least several metabolic pathways are involved in its analgesic and antipyretic action. ![]() Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in the world. ![]()
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